Lotilaner at a minimum dose rate of 20 mg/kg began to kill ticks on dogs within 4 h of treatment and efficacy was 100% within 8 h. Lotilaner sustained a rapid kill of newly infesting I. ricinus through 35 days.
Study 3 evaluated the speed of kill of lotilaner tablets against adult I. ricinus ticks, 12, 18 and 24 hours post-treatment and subsequent weekly infestations, following a single oral administration to …
Lotilaner tablets had proven to be efficacious against the main European cat tick (Ixodes ricinus) in three pivotal laboratory studies  while its efficacy against all ticks of relevance in
Laboratory evaluation of the efficacy and speed of kill of lotilaner (CredelioTM) against Ixodes ricinus ticks on cats Daniela Cavalleri, Martin Murphy, Wolfgang Seewald, Jason Drake and Steve Nanchen. Parasites & Vectors 2018 11:413 Published on: 13 July 2018 >Full text >PDF
Following oral administration under fed conditions, peak lotilaner concentrations are reached within two hours, with a corresponding rapid onset of activity against fleas and ticks [15, 16, 17]. Lotilaner efficacy has been demonstrated against a number of tick species including, but not limited to, Rhipicephalus sanguineus (sensu lato), Dermacentor reticulatus, Dermacentor variabilis, Ixodes scapularis, Ixodes …
Study 2 evaluated the speed of kill of lotilaner against C. felis, in cats, 8 and 12 h after treatment and after each subsequent weekly infestation, through day 35.
«Laboratory evaluation of the speed of kill of lotilaner (Credelio) against Ixodes ricinus ticks on dogs.» Parasites & Vectors 10:541. 5 Cavalleri D. et al. 2017. «Assessment of the speed of flea kill of lotilaner (Credelio) throughout the month following oral administration to dogs.» Parasites & Vectors 10:529.
Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats Parasites & Vectors 2018 11:408 Cavalleri D et al. A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe.
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Laboratory evaluation of the efficacy and speed of kill of lotilaner (CredelioTM) against Ixodes ricinus ticks on cats Daniela Cavalleri , Martin Murphy , Wolfgang Seewald , …
Lotilaner, an isoxazoline with rapid onset of action, has proven its efficacy against ticks in laboratory studies. A study was undertaken to confirm lotilaner’s efficacy and safety in client-owned cats, at the minimum dose of 6.0 mg/kg, against the most common ticks infesting cats in Europe.
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Ticks. For all experiments, laboratory-reared, unfed Ixodes ricinus nymphs free of borreliae and TBE virus were used. Ticks in the first test series were used 23–27 weeks after their previous blood meal and were kept at 20 °C, 90% relative humidity (r.h.), and long day (16 h light:8 h darkness).
Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs. Parasites & Vectors,10:541. CREDELIO demonstrated > 97% effectiveness against