The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer.

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The BAX/BAK-like protein BOK is a prognostic marker in

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer Steven Carberry1,BeatriceD’Orsi1,2, Naser Monsefi1, Manuela Salvucci1,OrnaBacon1,3,JoannaFay4, Markus Rehm 1,5, Deborah McNamara3, Elaine W. Kay4 andJochenH.M.Prehn1 Abstract The intrinsic or mitochondrial apoptosis pathway is controlled by the interactionof

The BAX/BAK-like protein BOK is a prognostic marker in

BOK protein levels in tumours were also prognostic of clinical outcome but increased BOK protein levels surprisingly associated with earlier disease recurrence and reduced overall survival.

Carberry et al. accepted for publication in Cell Death and

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. Carberry S, D’Orsi B, Monsefi N, Salvucci M, Bacon O, Fay J, Rehm M, McNamara D, Kay EW, Prehn JMH.

Carberry et al. accepted for publication in Cell Death and

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. Carberry S, D’Orsi B, Monsefi N, Salvucci M, Bacon O, Fay J, Rehm M, McNamara D, Kay EW, Prehn JMH.

ApoList – February 2018 – Apoptosis and cell death

Mar 02, 2018 · The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer Steven Carberry, Beatrice D’Orsi, Naser Monsefi, Manuela Salvucci, Orna Bacon, Joanna Fay, Markus Rehm, Deborah McNamara, Elaine W. Kay & Jochen M. H. Prehn

Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with

The potential prognostic and predictive significance of Bax and Bcl-2 gene expression and Bax/Bcl-2 ratio were demonstrated in colorectal cancer. The significant correlation between qPCR data and different clinicopathologic parameters of colorectal carcinoma, including age, gender, tumor size, tumor stage, tumor location, and tumor differentiation was also examined.

BCL-2 system analysis identifies high-risk colorectal

BOK protein levels in tumours were also prognostic of clinical outcome but increased BOK protein levels surprisingly associated with earlier disease recurrence and reduced overall survival.

Analysis of the p53/BAX Pathway in Colorectal Cancer: Low

CONCLUSION: We conclude that low BAX expression is an independent negative prognostic marker in patients with hepatic metastases of colorectal cancer. The best survival was seen in patients with an intact p53-to-BAX pathway; ie, wild-type p53- and BAX-positive tumors.

Bax protein may influence the invasion of colorectal cancer

Feb 07, 2014 · Bax protein seems to participate in colorectal cancer cell spread, which may indicate this protein’s participation in the early stages of colorectal cancer progression. However, Ogura et al[ 21 ] observed that a positive Bax expression is related with a smaller cancer …

Bax, Bcl-2, and Bax/Bcl-2 as Prognostic Markers in Acute

18 Katkoori VR, Suarez-Cuervo C, Shanmugam C, et al. Bax expression is a candidate prognostic and predictive marker of colorectal cancer. J Gastrointest Oncol. 2010;1:76–89.

BAX | Cancer Genetics Web

At the mechanistic levels, treatment with the aRVS extract led to the downregulation of Bcl-2 and Mcl-1 proteins, the activation of caspase-9/-3 proteins, an increase in cytosolic cytochrome c levels, the upregulation of Bax protein, an increase in phosphorylated p53 protein but a decrease in phosphorylated S6 protein in the A549 cells.

Beatrice D’Orsi – Senior Postdoctoral Researcher

Adaptable and innovative qualified Senior Postdoctoral Researcher with 6 years Postdoc experience in Neuroscience and Cancer research with a strong academic …

regulation of BOK expression by recruitment of TRIM28 to

76 in late stage (lymph node positive) versus early stage non-small cell lung cancer patients, 77 with high BOK protein levels being predictive of extended patient survival (Moravcikova et 78 al., 2017). Likewise, BOK was shown to be downregulated and of prognostic …

Analysis of the p53/BAX Pathway in Colorectal Cancer: Low

CONCLUSION: We conclude that low BAX expression is an independent negative prognostic marker in patients with hepatic metastases of colorectal cancer. The best survival was seen in patients with an intact p53-to-BAX pathway; ie, wild-type p53- and BAX-positive tumors.