Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication

Transcript availability dictates the balance between

Here, we show that there is little or no strand-asynchronous mtDNA replication when and where there is a dearth of transcripts, as predicted by the bootlace mechanism of mtDNA replication. Hence, we conclude that strand-asynchronous mitochondrial DNA replication is substantially a transcript-dependent mechanism.

Papers – Kazak Lab

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication. Nucleic Acids Research. 2. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, and Rosen ED. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin.

Mammalian mitochondrial replication : identification of

Hence, replication switches to a strand-coupled mechanism only where transcripts are scarce, thereby establishing a direct correlation between transcript availability and the mechanism of replication.

(PDF) A mitochondrial isoform of FEN1 functions as a

Hence, replication switches to a strand-coupled mechanism only where transcripts are scarce, thereby establishing a direct correlation between transcript availability and the mechanism of replication.

Detection of a specific mitochondrial DNA deletion in

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication. Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2. Related articles in.

Publications Authored by Tricia Cluett | PubFacts

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication.

Replication of mitochondrial DNA occurs by strand

The historical model of mammalian mtDNA replication. The strand-asynchronous displacement model for mammalian mtDNA replication was initially proposed based on the topology of single- and double-stranded replicative intermediates observed using electron microscopy (EM).

Published in: Genes & Development · 2005Authors: Timothy A Brown · Ciro Cecconi · Ariana N Tkachuk · Carlos Bustamante · David A Cl…About: Mitochondrial DNA · Branch migration · DNA replication · Gel electrophoresis · Ato…

Papers with the keyword mitochondrial transcription factor

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication. Tricia J Cluett, Gokhan Akman, Aurelio Reyes, Lawrence Kazak, Alice Mitchell, Stuart R Wood, Antonella Spinazzola, Johannes N Spelbrink, Ian J Holt

Papers with the keyword Rna helicase (Page 3) | Read by QxMD

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication.

The interface of transcription and DNA replication in the

DNA replication of the mitochondrial genome is unique in that replication is not primed by RNA derived from dedicated primases, but instead by extension of processed RNA transcripts laid down by the mitochondrial RNA polymerase.

Genetics Exam 1 Flashcards | Quizlet

T-DNA is generated when a nick at the left boarder creates a primer for synthesis of a new DNA strand. Transfer of T-DNA is initiated when DNA synthesis reaches a nick at the right border. T-DNA is transferred as a complex single stranded DNA with the virE2 single strand-binding protein and virD2 bound at the 5 terminus.